Transient increases in serum digoxin concentrations have been reported with concomitant administration of felodipine.

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diuretics eg, furosemide, hydrochlorothiazide because the risk of low blood potassium levels may be increased catechol-o-methyltransferase comt inhibitors eg, entacapone , maois eg, phenelzine , short-acting sympathomimetic bronchodilators eg, metaproterenol , stimulants eg, amphetamine , sympathomimetics eg, pseudoephedrine , or tricyclic antidepressants eg, amitriptyline because they may increase the risk of ventolin s side effects beta-blockers eg, propranolol because they may decrease ventolin s effectiveness digoxin because its effectiveness may be decreased by ventolin.

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typically occurs in the context of intercurrent illness, especially with impaired renal function clinical features are a combination of toxicity and the intercurrent illness symptoms may have an insidious onset over days to weeks features include those of acute digoxin toxicity as well as visual disturbances e.

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to explore whether gender was an effect modifier of the relationships between digoxin and mortality outcomes, we also fit versions of the multivariate cox proportional hazards models with a first-order interaction term between digoxin and gender.

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because of altered digoxin distribution and elimination, projected peak body stores for patients with renal insufficiency should be conservative see precautions .

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