Minocycline, a second-generation tetracy- cline antibiotic, selectively targets microglia and can meet the bloodbrain limit.

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the pharmacokinetics of minocycline in patients with renal impairment clcr 80 ml min have not been fully characterized.

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also, despite significant mri disease-activity pretreatment 19 40 scans had gadolinium-enhancing activity during a three-month run-in , the only patient with gadolinium-enhancing lesions on mri at 12 and 24 months was on half-dose minocycline.

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aluminum salts eg, aluminum carbonate or cimetidine because they may decrease minocycline s effectiveness.

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attenuation of morphine tolerance by minocycline and pentoxifylline in naive and neuropathic mice.

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